A new paper is published from bioRxiv. (2020-08-24)
This manuscript is now under review.Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection
IIDA K., Ajiro M., Muramoto Y., Takenaga T., Denawa M., Kurosawa R., Noda T., and Hagiwara M.
This paper reports that manipulating RNA splicing of OAS1 with small molecule compounds enhances innate immunity in human cells, and provides the cells with resistance to SARS-CoV-2 virus infection.
A paper by Dr. Masahiko Ajiro is published from Nature Communications. (2021-07-23)
I have contributed on analysis for spllicing changes in small chemical compound: RECTAS treated cells and mice.Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia
Ajiro M., Awaya T., Kim Y.J., Iida K., Denawa M., Tanaka N., Kurosawa R., Matsushima S., Shibata S., Sakamoto T., Studer R., Krainer A.R., and Hagiwara M.
A paper by Dr. Simon Uzor and Prof. Michael R. Ladomery is published from Scientific Reports. (2021-04-12)
I have contributed on analysis for spllicing changes in CLK-inhibitor treated cells.CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
Uzor S., Porazinski S.R., Li L., Clark B., Ajiro M., Iida K., Hagiwara M., Alqasem A.A., Perks C.M., Wilson I.D., Oltean S., and Ladomery M.R.
Dr. Kazuo Shinozaki, my great mentor when working at RIKEN, was selected a member for The American Society of Plant Biologists. (2021-03-11)
So happy news!
A paper by Dr. Masayasu Toyomoto is published from Cell Chemical Biology. (2021-02-08)
I have contributed on prediction of ALESIA-targeting pathway, based on RNA-seq analysis.S1PR3-12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
Toyomoto M., Inoue A., Iida K., Denawa M., Kii I., Ngako Kadji F.M., Kishi T., Im D., Shimamura T., Onogi H., Yoshida S., Iwata S., Aoki J., Hosoya T., and Hagiwara M.
A paper by Dr. Akihide Takeuchi is published from Stem Cell Reports. (2020-10-13)Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage
Takeuchi A., Takahashi Y., Iida K., Hosokawa M., Irie K., Ito M., Brown J.B., Ohno K., Nakashima K. and Hagiwara M.
A new papar is published from iScience. (2020-06-27)
Multilateral bioinformatics analyses reveal the function-oriented target specificities and recognition of the RNA-binding protein SFPQ
IIDA K., Hagiwara M., and Takeuchi M.
It's reporting a novel bioinformatics method to find functionally essential interactions between RNA and proteins from CLIP-seq data.
Web-site is open. (2020-06-25)