Web page of Kei IIDA @KINDAI Univ. Japan.

News

(Go to Japanease Contents / 日本語のページはこちら)

• A new paper is published from Scientific Reports (2022-09-28)
  

  Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage.
  Kusaka M, Hasegawa T, Ikeda HO, Inoue Y, Iwai S, Iida K , Tsujikawa A.
  DOI: https://doi.org/10.1038/s41598-022-20497-w
  This paper reports a hypothetical molecular mechanis with which cell death in retinal ganglion cells of glaucoma mouse models suppressed.

• A new paper is published from ACS Chem Biol. (2022-09-23)
  

  Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding.
  Takashima Y, Murata A, Iida K, Sugai A, Hagiwara M, Nakatani K.
  DOI: https://doi.org/10.1021/acschembio.2c00452
  This paper reports a method to seek inhibision targets of a small chemical compound, about miRNA maturations

• A new paper is published from Cancer Reports. (2022-08-09)
  

  Identification of the α2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models
  Nagai T., Terada N., Fujii M., Nagata Y., Nakahara K., Mukai S., Okasho K., Kamiyama Y., Akamatsu S., Kobayashi T., Iida K., Denawa M., Hagiwara M., Inoue T., Ogawa O., and Kamoto T.
  DOI: https://doi.org/10.1002/cnr2.1701
  This paper reports α2 chain of interleukin-13 receptor (IL13RA2) as a potential expression markar for prostate cancer.

• I join Prof. Haruhisa Inoue’s lab, CiRA, Kyoto University, as a part-time researcher. (2022-06-29)
  I’m involved in genome study about ALS.
  
  

• I start a new work at Kindai University. (2022-04-01)
  I host Biological Data Science Laboatory.
  
  

• A new paper is published from bioRxiv. (2021-08-24)
  This manuscript is now under review.

  Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection
  IIDA K., Ajiro M., Muramoto Y., Takenaga T., Denawa M., Kurosawa R., Noda T., and Hagiwara M.
  DOI: https://doi.org/10.1101/2021.08.23.457314
  This paper reports that manipulating RNA splicing of OAS1 with small molecule compounds enhances innate immunity in human cells, and provides the cells with resistance to SARS-CoV-2 virus infection.

• A paper by Dr. Masahiko Ajiro is published from Nature Communications. (2021-07-23)
  I have contributed on analysis for spllicing changes in small chemical compound: RECTAS treated cells and mice.

  Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia
  Ajiro M., Awaya T., Kim Y.J., Iida K., Denawa M., Tanaka N., Kurosawa R., Matsushima S., Shibata S., Sakamoto T., Studer R., Krainer A.R., and Hagiwara M.
  DOI: 10.1038/s41467-021-24705-5
  

• A paper by Dr. Simon Uzor and Prof. Michael R. Ladomery is published from Scientific Reports. (2021-04-12)
  I have contributed on analysis for spllicing changes in CLK-inhibitor treated cells.

  CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
  Uzor S., Porazinski S.R., Li L., Clark B., Ajiro M., Iida K., Hagiwara M., Alqasem A.A., Perks C.M., Wilson I.D., Oltean S., and Ladomery M.R.
  DOI: 10.1038/s41598-021-86908-6
  

• Dr. Kazuo Shinozaki, my great mentor when working at RIKEN, was selected a member for The American Society of Plant Biologists. (2021-03-11)
  So happy news!
  
  

• A paper by Dr. Masayasu Toyomoto is published from Cell Chemical Biology. (2021-02-08)
  I have contributed on prediction of ALESIA-targeting pathway, based on RNA-seq analysis.

  S1PR3-₁₂-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation
  Toyomoto M., Inoue A., Iida K., Denawa M., Kii I., Ngako Kadji F.M., Kishi T., Im D., Shimamura T., Onogi H., Yoshida S., Iwata S., Aoki J., Hosoya T., and Hagiwara M.
  DOI: 10.1016/j.chembiol.2021.01.004
  

• A paper by Dr. Matsunaga Mami is published. (2020-11-17)
  I joined this work as Bioinformatics Support Service.
  
  

• A paper by Dr. Akihide Takeuchi is published from Stem Cell Reports. (2020-10-13)

  Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage
  Takeuchi A., Takahashi Y., Iida K., Hosokawa M., Irie K., Ito M., Brown J.B., Ohno K., Nakashima K. and Hagiwara M.
  DOI: 10.1016/j.stemcr.2020.08.010
  

• A new papar is published from iScience. (2020-06-27)
  

  Multilateral bioinformatics analyses reveal the function-oriented target specificities and recognition of the RNA-binding protein SFPQ
  IIDA K., Hagiwara M., and Takeuchi M.
  DOI: https://doi.org/10.1016/j.isci.2020.101325
  It's reporting a novel bioinformatics method to find functionally essential interactions between RNA and proteins from CLIP-seq data.

• Web-site is open. (2020-06-25)